Prejunctional Regulation by Endogenous and Exogenous Acetylcholine of Adrenergic Nerve Function in Isolated Canine Mesenteric Arteries.
نویسندگان
چکیده
منابع مشابه
Differences in adrenergic nerve and receptor function in dog internal thoracic, coronary and mesenteric arteries.
Isolated dog internal thoracic arteries (ITA) responded to norepinephrine and phenylephrine with concentration-related contractions, which were suppressed by prazosin, but not by yohimbine. Clonidine did not contract ITA. In coronary arterial strips, norepinephrine produced a relaxation. Isoproterenol relaxed coronary arterial strips contracted with serotonin but did not alter the tone of ITA. ...
متن کاملPrejunctional and postjunctional actions of endogenous norepinephrine at the sympathetic neuroeffector junction in canine coronary arteries.
The effects of endogenous and of exogenous norepinephrine were studied in isolated rings of canine left circumflex coronary artery and its first ventricular branch. Norepinephrine was released from adrenergic nerve endings by transmural electrical stimulation and by tyramine. In rings contracted with prostaglandin F2 alpha, transmural electrical stimulation resulted in frequency-dependent relax...
متن کاملAdrenergic stimulation-released 5-HT stored in adrenergic nerves inhibits CGRPergic nerve-mediated vasodilatation in rat mesenteric resistance arteries.
BACKGROUND AND PURPOSE 5-HT is taken up by and stored in adrenergic nerves and periarterial nerve stimulation (PNS) releases 5-HT to cause vasoconstriction in rat mesenteric arteries. The present study investigated whether PNS-released 5-HT stored in adrenergic nerves affects the function of perivascular calcitonin gene-related peptide-containing (CGRPergic) nerves. EXPERIMENTAL APPROACH Rat ...
متن کاملModulation by neurogenic acetylcholine of nitroxidergic nerve function in porcine ciliary arteries.
PURPOSE To determine whether nitroxidergic, cholinergic, and vasoactive intestinal polypeptide (VIP)-mediated nerves participate in the regulation of porcine ciliary arterial tone and to analyze the mechanisms underlying the neuronal interaction. METHODS Changes in isometric tension were recorded in helical strips of the arteries, which were stimulated by transmurally applied electrical pulse...
متن کاملInsulin inhibits acetylcholine responses in rat isolated mesenteric arteries via a non-nitric oxide nonprostanoid pathway.
Hyperinsulinemia is a risk factor for hypertension and arteriosclerosis. The mechanism by which it contributes to disease progression is not known. The present study examines the effects of insulin on endothelium-derived relaxing factors. Segments of rat mesenteric arterioles and aorta were set up for isometric recordings. The effect of insulin (1 mU/mL) on acetylcholine responses was examined ...
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ژورنال
عنوان ژورنال: Hypertension Research
سال: 1997
ISSN: 0916-9636,1348-4214
DOI: 10.1291/hypres.20.119